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Chronic inflammation and lipid accumulation in the liver, driven by obesity, activate TGF- signaling pathways, promoting hepatic fibrosis and metabolic dysregulation

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At 48 weeks, the least-squares mean percentage change in body weight was -8.7% in the 1 mg group, -17.1% in the combined 4 mg group, -22.8% in the combined 8 mg group, and -24.2% in the 12 mg group, compared with -2.1% in the placebo group

(7) Following the absorption of food, GLP-1 and GIP promote insulin secretion, otherwise known as the incretin effect

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