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Those with copper or nickel contact allergy: a documented metal sensitivity increases the likelihood of allergic contact dermatitis

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

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Diabetes Obes Metab (2021) 23 Suppl 3:529