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They discovered that both patient groups exhibited signs of elevated oxidative stress

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14 Two therapeutic strategies currently exist to overcome the short half-life of incretin hormones and pharmacologically augment the incretin effect: 1) inject GLP-1 receptor agonists that are resistant to degradation by the DPP-4 enzyme and 2) orally administer DPP-4 inhibitors that delay the enzymatic degradation of naturally secreted incretin hormones ( Figure 2 )

These two work together to facilitate stable blood sugar and weight loss. In clinical trials, people lost an average of 16% of their body weight on a 5 mg dose of tirzepatide, 21.4% on 10 mg, and 22.5% on 15 mg

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