While in this model, choline deprivation altered lipid composition in the liver, decreasing sphingomyelin and specific glycerophospholipids with 34:1 fatty acids, leading to reduced inflammation, its impact on brain lipid metabolism was less pronounced (101)
some may experience more significant reductions in abdominal fat, while others may see more uniform fat loss across the body
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A critical challenge for future clinical studies will be the robust assessment of treatment effects on in situ fibrosis