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This predisposes to repeated microtrauma and dystrophic nail changes, which may acquire a grayish-brown color with transverse ridges resembling a seashell (Fig
Diabetes 59 , 10301037 (2010)
No dose adjustment is required for patients with renal impairment (including end-stage renal disease) or hepatic impairment, as pharmacokinetic differences are not clinically meaningful
Semaglutide is injected subcutaneously (under the skin), typically in the abdomen or thigh
It is helpful for those who have not had success with traditional diet and exercise alone
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