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Dankner R et al

Metformin, the second most commonly prescribed medication in the US in 2023, was first synthesized by scientists in 1922 and has been widely used to treat type 2 diabetes since the mid-20th century

No medical, therapeutic, or dosing claims are made

The first study identified N -acetyl-aspartyl-glutamate (NAAG), which can be hydrolyzed to glutamate when needed by the oncogenic cells via glutamate carboxypeptidase II (GCP II) [41, 42], suggesting that GCPII is a viable target for cancer therapy, either alone or in combination with glutaminase inhibition

Understanding GLP-1 and Dual Agonist Medications Semaglutide (the active ingredient in Ozempic, Wegovy, and Rybelsus) mimics a natural GLP-1 hormone that regulates blood sugar and appetite

Additionally, GLP-1 receptor agonists can influence the gut microbiome, which may have complex effects on cancer development