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In homeostasis conditions, GSH is the most efficient physiological reducing agent with the highest bioavailability (~ 10 mM) in the intracellular environment where it is synthesized, except in epithelial cells [23]

This finding suggested that GH secretagogues might have therapeutic potential for steroid-induced osteoporosis, though this has not been tested in human trials

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Observational real-world data in patients with T2D receiving oral semaglutide for 26 weeks demonstrated preservation of fat-free and skeletal muscle mass despite significant losses in fat mass and visceral adipose tissue, suggesting that the magnitude of lean tissue change may depend on concomitant lifestyle behaviors, such as physical activity and diet [16]

J., & Leppert, P