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Researchers said weight regain has been reported after stopping other obesity medications, and overall data confirm the chronicity of obesity and highlight the importance of maintaining long-term pharmacological treatment for weight management in people with obesity. The success of GLP-1 medications can depend on how long people use them
570,571 For example, based on the unique mechanism of action of ASOs, the main safety issues are severe hepatotoxicity and nephrotoxicity caused by drug accumulation
While negotiating additional rebates can lower drug spending, the perverse incentive may encourage PBMs to exclude or prevent access to high-quality, therapeutic alternatives that are cheaper for payer and patient
Mishra, D
Resources: Pickart, L., & Margolina, A
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