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Accelerating escalation is generally not recommended, as the gradual protocol serves important pharmacodynamic purposes beyond simple tolerability

Thats because neither its therapeutic potential nor its safety has been tested on people

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Retatrutide is at the Phase 3 stage, and the cagrilintide-plus-semaglutide combination CagriSema was reported to have a New Drug Application under FDA review, but a filing under review is not an approval

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