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Collectively, GLP-1-RAs are involved in the regulation of DNP mainly through the suppression of matrix remodeling, inflammation, oxidative stress, and mitochondrial dysfunction, as well as the improvement of neural structure and function [90,91,92,93] (Fig

134,135 Research has indicated that stimulating GLP-1R may reverse certain changes associated with cellular aging, including the shortening of telomeres and the impairment of DNA repair mechanisms

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This helps avoid skin irritation or unnecessary tissue trauma

It does not diagnose, treat, or recommend medical use