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Regulatory Considerations FDA Approval -Tesamorelin is FDA-approved for reducing visceral fat in patients with HIV-associated lipodystrophy, while Sermorelin is not FDA-approved for any specific indication, though it is commonly prescribed by some physicians for off-label uses, such as muscle growth, anti-aging, and general growth hormone optimization
But a follow-up 2021 study, known as STEP 4, showed that within 48 weeks of no longer taking semaglutide, participants regained approximately two-thirds of their prior weight loss, while those who remained on GLP-1 drug therapy continued to lose weight
Some users query why theyre still hungry on semaglutide, or why theyre not losing weight on semaglutide as expected
However, this was a small study of 48 individuals and more research is needed to inform clinical decision making and treatment guidelines