Anti-obesity drug therapy can be offered as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adult patients with an initial body mass index (BMI) of 30 kg/m 2 or 2730 kg/m 2 in the presence of at least one weight-related comorbidity, e.g., dysglycemia, hypertension, dyslipidemia, or obstructive sleep apnea

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IDH1/2 use NADP + as a cofactor and conduct a reversible reaction, while IDH3 uses NAD + as a cofactor and conducts irreversible conversion
Posible reduccin del riesgo cardiovascular para algunos pacientes