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GH-sufficient adults have intact feedback mechanisms

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It happens with any form of rapid weight losswhether from bariatric surgery, severe calorie restriction, or illness

Moreover, a study found that patients enrolled in the RELAX-AHF trial were largely unrepresentative of global AHF patients, as it only represented 20% of AHF patients in the United States, Latin America or Asian-Pacific region

As with any medication, it's important to approach their use under medical guidance to ensure safety and effectiveness