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Structurally, the protein comprises an extracellular region with three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain
Curcumin modulates critical pathways such as NF-B and downregulates IL-6 and TNF- signaling, leading to improvements in both glucose metabolism and depressive symptoms (Sarmiento-Ortega et al., 2025
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[16] [17] Semaglutide (as Wegovy) is further indicated as an adjunct to a reduced-calorie diet and increased physical activity for weight management, including weight loss and weight maintenance, in adults with obesity (initial BMI 30 kg/m 2 ) or who are overweight (initial BMI 27 kg/m 2 ) and have at least one weight-related comorbidity such as dysglycemia (prediabetes or type 2 diabetes), hypertension, dyslipidemia, or cardiovascular disease
Both preclinical and clinical studies have demonstrated that GLP-1s modulate the gut microbiota composition by delaying gastric emptying and altering luminal glucose (12)
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