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While semaglutide does not require dose adjustment for mild to moderate renal impairment, experience in patients with severe renal impairment is limited

Krivic et al

That said, in humans the data are less robust than for some other sleep interventions, so effective depends on how you define it (improvement vs complete resolution of poor sleep quality)

These effects make it useful for post surgical recovery research and chronic wound research

Cagrilintide's safety profile from Phase 3 (REDEFINE 1) showed: GI adverse events (nausea 44%, vomiting 24%, diarrhea 20%) comparable to semaglutide alone