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One notable distinction: PT-141 does not directly improve penile hemodynamics as potently as a PDE5i, so if a man has severe vascular issues, a PDE5i or injection is needed to get sufficient rigidity
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However, the authors stated this is not a clinically significant difference
Pohl et al
Gastrointestinal symptoms that dont improve when you eat smaller meals or take anti-nausea medications
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