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They are a clinically established treatment for B12 deficiency

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Other malabsorption causes include: Atrophic gastritis and reduced gastric acid production (common in older adults) Gastrointestinal surgery, particularly gastrectomy, ileal resection, or bariatric surgery (especially gastric bypass) Inflammatory bowel disease affecting the terminal ileum (Crohn's disease) Coeliac disease and other small bowel disorders Chronic pancreatitis affecting enzyme secretion Helicobacter pylori infection (may contribute to reduced absorption) Medication-related deficiency is increasingly recognised

Bias in meta-analysis detected by a simple, graphical test

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Better Mental Health and Mood Low levels of B12 have been linked to several mental health problems, such as depression and anxiety