These effects are initially mediated by natriuresis and plasma volume contraction, but sustained effects likely reflect additional mechanisms including reduced total body sodium, decrease in intracellular sodium and calcium, and vasodilation
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As the pharmacological action and impact on CV parameters interpreted from the CV outcomes trials seemingly differed between both classes of glucose-lowering agents, they should be used accordingly, that is, after taking into consideration a patients needs and drug tolerability
Zhou, Q., Verne, M
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