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Both alcohol and isoniazid induce CYP2E1 and affect APAP-induced ALI by increasing NAPQI, the hepatotoxic metabolite of APAP, indicating that CYP2E1 may be the major P450 contributing to conversion of APAP to NAPQI (Zand et al., 1993

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The Cochrane report (1) correctly separated a study showing the benefit of allopurinol or another antioxidant, dimethyl sulfoxide, in patients with a pancreatitis relapse (127), wherein many other factors such as pancreatic ischaemia come into play (23, 25), but was included in the other two appraisals (39, 178)

thaliana GrxS15, which has a CGFS-motif and only one cysteine residue in total (Fig