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doi: 10.1016/j.tem.2019.07.015 117 StepenskyD.FriedmanM.RazI.HoffmanA
Some debate exists about long-term use since obesity tends to be chronic, these medications likely need to be continued to maintain weight loss (as stopping leads to regain, based on observations)
One of the most remarkable advantages of tirzepatide treatment is the notable decrease in food obsession
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In February 2017, the European Medicines Agency (EMA) issued a warning concerning increased risk of lower limb amputation (especially toes) related to SGLT2 inhibitor therapy, although this risk was demonstrated to be significant only for canaglifozin [105]
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