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The combination has not shown any emergent toxicity beyond what would be expected from either peptide individually
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Abbreviations AD: Alzheimer disease A: Amyloid beta CI: Confidence interval DSM: Diagnostic and Statistical Manual of Mental Disorders DTBN: 5,5-Dithio-bis(2-nitrobenzoic acid) GSH: Glutathione HC: Healthy control MCI: Mild cognitive impairment MEGA-PRESS: Meshcher-Garwood Point-Resolved Spectroscopy MMSE: Mini-Mental State Examination MRS: Magnetic resonance spectroscopy OPA: O-Phthalaldehyde OS: Oxidative stress PRESS: Point resolved spectroscopy SMD: Standardized mean difference STEAM: STimulated Echo Acquisition Mode References Koyama A, O'Brien J, Weuve J, Blacker D, Metti AL, Yaffe K
Glutathione supplementation can also help to reduce chronic inflammation, oxidative stress, and cellular degeneration
Caraceni P, Van Thiel DH
Molecular cloning and identification of mouse epididymis-specific gene mHong1, the homologue of rat HongrES1
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