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[7] Amlodipine causes several drugs to increase in levels, including cyclosporine, simvastatin, and tacrolimus (the increase in the last one being more likely in people with CYP3A5*3 genetic polymorphisms)

NASH resolution: In trials specifically examining liver outcomes, a significant proportion of patients achieved resolution of NASH (the inflammatory form of fatty liver disease)

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While headache susceptibility isn't directly predicted, genetic insights help PlexusDx clinicians personalize your dose escalation and formulation choice to minimize early adjustment symptoms

See Exhibit 1 below

Macrophage Foaming: TMAO Promotes the Conversion of Macrophages Into Foam Cells As the major immune cells in atherosclerotic lesions, macrophages play a critical role in the development of atherosclerosis