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Their primary mechanisms of action include: Enhancing glucose-dependent insulin secretion from pancreatic beta cells Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates post-meal glucose spikes Reducing appetite through central nervous system effects, particularly in hypothalamic regions Promoting satiety , leading to reduced caloric intake These medications have demonstrated significant benefits in glycaemic control, weight reduction, and cardiovascular risk reduction in clinical trials

Caspases in cell death, inflammation, and pyroptosis

Muscle weakness typically results from loss of lean body mass during rapid weight loss, with approximately 2540% of total weight lost coming from muscle rather than fat