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Biochim Biophys Acta, 2013

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The dosing is gradually increased over time to reduce the chance of gastrointestinal discomfort, which is common during early weeks of treatment

The reasons for these changes, apart from excess ROS leading to increased GSH depletion in cardiomyocytes, are disturbances in the anabolic process of GSH, causing a further decrease in intracellular GSH content