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Depriving tumours of extracellular glutathione or inhibiting its breakdown is potentially a viable therapeutic strategy for cancer patients, the authors state

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SIDE EFFECTS The side effects of IGF-1 LR3 are directly related to its potent anabolic and metabolic effects

2.11 Separation and extraction of nuclear and cytoplasmic proteins In this experiment, nuclear and cytoplasmic fractionation was performed using the Nuclear and Cytoplasmic Protein Extraction Kit (Beyotime, P0027) following the manufacturers instructions

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That is because the administration of ascorbate into a high oxidative stress environment increases tissue concentrations of glutathione, indicating that ascorbate (vitamin C) spares glutathione