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Commonly reported GLP-1 adverse effectsincluding nausea, vomiting, constipation, and abdominal discomfortsubstantially overlap with symptoms of an IBD flare, which may complicate safety monitoring and clinical assessment

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The neurological phenotype of FRDA includes cerebellar atrophy in the dentate nucleus, the dorsal root ganglia become smaller, reduction in the spinal cord diameter, and loss of corticospinal and spinocerebellar tracts (Koeppen, 2011

Potential measurements include: Cell-count changes DNA-synthesis assays Cell-cycle phase distribution Metabolic viability assays Colony formation Apoptosis-associated markers Membrane-integrity measurements Senescence-associated markers Increased proliferation is not automatically beneficial and does not establish tissue regeneration

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Elife 6 , e21036 (2017)