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CULLIN-RING ligases (CRLs) are the largest family of E3 ubiquitin ligases in eukaryotes, utilizing CULLIN proteins (CULLIN1, 2, 3, 4 A, 4B, 5, 7, 9) as scaffolds 5

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Furthermore, we found that HFD consumption also led to decreased hepatic expression of glutaredoxin, a key enzyme for de-glutathionylation

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