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In four randomized controlled trials (RCT) conducted in patients with obesity without T2D 15,16,17,18 , liraglutide 3.0 mg was compared to placebo as an adjunct to lifestyle optimization over 56 weeks, with the exception of the 3-year extension of the SCALE Obesity and Prediabetes study
Dual glucagon (GCGR)/GLP-1RAs, such as survodutide, have demonstrated potential in the treatment of MASH
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Also, the lack of a comprehensive analysis of muscle mass across multiple muscle groups and tissues may have limited our ability to fully assess the impact of GLP-1 analogs on muscle health
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