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The MC1R gene is among the most polymorphic in the human genome and with numerous loss-of-function variants associated with red hair, fair skin, increased UV sensitivity, and elevated melanoma risk , and MT-1 is used as a research tool for studying how MC1R polymorphisms influence receptor function, signalling capacity, and downstream melanogenesis and photoprotection biology

Some of the risk factors for lupus include a diet limited in adequate nutrients, food allergies and sensitivities, and gastrointestinal disturbances which may manifest as leaky gut syndrome

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Acknowledgements Authors are grateful to Panjab University, Chandigarh, India for facilities