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A 10-year longitudinal follow-up of a retrospective cohort comprising 159 patients with PCOS treated with metformin reported that the total testosterone and androstenedione decreased to 15.4 47.9% and 11.3 46.4% within first year, with further decrease in total testosterone and androstenedione to 37.8 61.8 and 24.8 40.5% at the fifth year of the follow-up (38, 39)
A large-scale observational study published in 2023 analyzed electronic health records of over 80,000 patients with obesity and found that those prescribed semaglutide had a 50-56% lower risk of alcohol use disorder compared to those on other obesity medications
But while these medications offer unprecedented promise in weight loss and cardiometabolic care, they also present significant cost and care challenges
They explain why recovery may feel slower on GLP-1 therapy, but they do not represent permanent limitations
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