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Furthermore, the gut microbiota might play a role to modulate bile acid synthesis in the liver by alleviating FXR inhibition through TMCA, a reported FXR antagonist 33

You start at 0.25 mg weekly for the first four weeks, then increase to 0.5 mg for weeks 5 through 8, then 1 mg for weeks 9 through 12, then 1.7 mg for weeks 13 through 16, and finally the maintenance dose of 2.4 mg from week 17 onward

Vitamin B12 (also known as cobalamin) is a water-soluble vitamin that plays an important role in metabolism, red blood cell formation, and nerve function

4B), indicating an active bile acid dehydroxylation in these mice

BPC 157 is a naturally occurring peptide fragment