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Evidence-based weight management includes intensive lifestyle modification with dietary counseling and physical activity, FDA-approved medications (prescription GLP-1 agonists, phentermine-topiramate, naltrexone-bupropion, orlistat), behavioral therapy, and metabolic/bariatric surgery for eligible patients

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A clinical trial of sitagliptin in a small sample of patients with impaired glucose tolerance and mild T2DM found significant reductions in carotid intimal thickness in sitagliptin compared with diet control alone [122]

It needs to be physically strong (to prevent unwanted particles from entering the bloodstream) and chemically protected (to manage inflammation)

The study, led by Raphael Cuomo, Ph.D., associate professor in the Department of Anesthesiology at UC San Diego School of Medicine and member of UC San Diego Moores Cancer Center, used real-world clinical data from the University of California Health Data Warehouse to assess outcomes across the states academic medical centers

Ann Rheum Dis (2020) 79(6):68599