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Oncogene 2015;34:561725
Can it really increase your lifespan
In summary, our findings indicate that BRAFi-resistant cells exhibit increased intracellular or mitochondrial ROS, decreased of GSH levels, elevated long-chain PUFAs, and enhanced lipid peroxidation
Due to oxidative stress and hypoxia in tumor microenvironments, GSH concentrations can be further elevated in cancer cells which is beneficial to the rapid specific release of payload inside cancer cells 4 when disulfide bond linkers were used
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