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Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD
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Bloating and Abdominal Distension: Individuals with gastroparesis frequently describe a sensation of bloating or a distended abdomen, creating discomfort and unease
Chemically modified superoxide dismutase (carboxymethylcellulose-SOD and polymethylvinylether-maleic anhydride copolymer-SOD) is effective in the treatment of diabetes and has a therapeutic advantage in clinical use
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