Precision-medicine frameworks now aim to classify PD patients into microbiome-immune subtypes, allowing for specific combination therapies, such as pairing SCFA-restoring strategies with T-cell modulation in Th17-dominant endotypes or combining barrier-repair interventions with microglial inhibitors in patients with strong peripheral-to-central inflammatory coupling
Rametta R, Fracanzani AL, Fargion S, Dongiovanni P
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The heart was exposed via a left thoracotomy, and a 4-0 (rats) or 8-0 (mice) Prolene suture was passed around the left anterior descending (LAD) coronary artery to induce a temporary occlusion
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