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Ideal candidates for our program often have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with weight-related health conditions such as type 2 diabetes, hypertension, or sleep apnea
Phase 2 trial data (NEJM 2023) showed approximately 17.5% mean body weight reduction at 24 weeks at the highest dose, but week-4 figures were not reported as a primary endpoint
Individual speakers at a 2024 National Academies workshop suggested that GLP-1R agonists may reach the brain mainly through specialised uptake at the circumventricular organs, regions that sit outside the standard barrier, rather than by penetrating it
A combined approach offers the most comprehensive benefits
avoidance recommended as a precaution Active malignancy: Pro-angiogenic mechanism warrants caution until more data is available History of hormone-sensitive cancers: Discuss thoroughly with your physician Severe coagulation disorders: Given vascular effects, clinical assessment required Patients on certain anticoagulants: Monitoring required
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