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An apparent paradox is that whereas GLP-1 increases glucose-stimulated insulin secretion in the isolated pancreas fulfilling the definition of an incretin but it lowers insulin secretion in physiologically relevant conditions [6, 10, 18]
Everything else about how they differ flows from that one distinction
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Rather than daily injections, the protocol requires a heavier 2.5 mg systemic dose injected twice per week
doi:10.1038/ejcn.2009.68 23
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