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GSH is synthesized de novo in the brain by astrocytes and research has demonstrated increased GSH synthesis during oxidative stress-related toxicity in vitro , proposing in vivo synthesis of this antioxidant might be sufficient to not detect significant changes ( 4.2

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Soto, J., Rivera, M., Broitman-Maduro, G

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However, it is important to recognise that whilst they are widely available, the regulatory framework for food supplements differs significantly from that of licensed medicines, and claims made about their efficacy should be evaluated critically against available evidence

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Br J Pharmacol (2012) 167(5):1099110

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