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Choline diet and its gut microbe-derived metabolite, trimethylamine n-oxide, exacerbate pressure overload-induced heart failure
Blood cell production typically begins improving within 35 days, haemoglobin rises over 12 months, whilst neurological recovery may take several months
Investigational doses range from 250mcg to 2mg administered subcutaneously daily or every other day, with side effect incidence increasing at higher doses
You may wake up more rested and feel a subtle uptick in daily energy
Further translational research and prospective clinical trials are required to clarify causality, determine effect size, and identify high-risk groups most likely to benefit
Australian Government
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