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B12 deficiency is more common than widely recognized, particularly in individuals who follow plant-based diets, take proton pump inhibitors or metformin, are over 50, or have gastrointestinal conditions affecting absorption

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GHK-Cu is understood to upregulate collagen synthesis in dermal fibroblasts, a mechanism explored in multiple studies, including research on copper peptides and skin regeneration published in Biomolecules , which also examined GHK's broader gene-modulating effects

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For them, vitamin B12 with cyanocobalamin supplements are essential

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