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Notably, glutathione balance and GPX4 levels are deeply involved in the susceptibility of cardiomyocytes to ferroptosis, a novel form of cell death

Molecular mechanisms underlying the impact of GLP-1RAs on cancer risk The regulation of cancer risk by GLP-1RAs involves several biological mechanisms, primarily encompassing metabolic regulation, direct anti-tumor effects, immune modulation, and epigenetic alterations

It works by: Slowing gastric emptying , which prolongs feelings of fullness after eating Reducing appetite through effects on brain regions that regulate hunger Improving glycaemic control by enhancing insulin secretion when blood glucose is elevated Reducing glucagon secretion , which helps prevent excessive glucose production by the liver The medication is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to the maintenance dose of 2.4 mg weekly (though some patients may remain on 1.7 mg if the higher dose is not tolerated)

J Biotechnol 290:1623

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