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The lack of FDA approval for cosmetic use reflects insufficient clinical evidence demonstrating safety and efficacy for skin lightening purposes

The normal function of this receptor is to respond to increased Ca 2+ in the blood and, upon receptor activation, lead to inhibition of Na + , Cl , Ca 2+ and Mg 2+ (as well as other divalent cations) reabsorption from the tubular lumen

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All statistical tests used a significance level of 0.05