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In its briefing materials, FDA staff concluded the evidence weighed against adding these peptides, citing limited proof of effectiveness, gaps in how the substances are chemically characterized, and unresolved questions about impurities and immune reactions

Melatonin production frequently declines with aging, resulting in irregular sleep patterns and poor sleep quality

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Pregnancy or breastfeeding, certain cancers, uncontrolled endocrine disorders, and medication interactions can be contraindications depending on the peptide

As with any supplement or medication, individual responses vary