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Rybelsus is the first oral GLP-1 receptor agonist and requires specific administration: it must be taken on an empty stomach with up to 120ml of water, swallowed whole, and followed by at least 30 minutes before eating, drinking or taking other oral medications

Proposed Mechanisms (Preclinical) Incretin & Glucose Pathways GLP-1 receptor activation: Investigated for effects on glucose-dependent insulin secretion, gastric emptying, and appetite-related signaling in CNS pathways

6 , e13685 (2018) S.H

Treatment continuation is usually reviewed at specified intervals, with discontinuation recommended if insufficient weight loss is achieved according to NICE criteria

H.RunhaarJ.van MiddelkoopM.et al (2019)

Huang, S.-C., Lin, Y.-K., Lin, Y.-H., Chan, S.-T., & Chiang, C.-F