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When both are activated simultaneously, the intracellular signalling cascades interact synergistically: CJC-1295 activates GHRHR increases intracellular cAMP activates protein kinase A enhances GH gene transcription and vesicle exocytosis

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Diabetes therapies are generally understood to be lifelong, with adjustments over time

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Ipamorelin (GHSR-1a agonist) and CJC-1295 (GHRH-R agonist) work through complementary and synergistic receptor pathways

Data 18 , 16371755 (1989)