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Cell 156 , 317331 (2014)
Research demonstrates that TB-500 administration mobilizes EPCs from bone marrow reservoirs, with animal studies showing 3-fold increases in circulating EPC numbers that contribute to neovascularization through both structural incorporation into developing vessels and paracrine secretion of pro-angiogenic factors
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This results in an increase in the cytoplasmic calcium concentration, which enhances insulin secretion from -cells [24,25,26] (Fig
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