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Methylation does not increase hydrophilicity because methyl group is lipophilic

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At 52 weeks, tirzepatide led to a reduction of 25.3 events/hour, compared to a reduction of 5.3 events/hour with the placebo, for a treatment difference of 20.0 events/hour

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doi: 10.1007/s11306-018-1448-3 24 HaJHJayaramanMNadhanRKashyapSMukherjeePIsidoroCet al

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