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Most therapeutic peptides require subcutaneous or intravenous administration

However, Spd and Spm also have a number of extracellular neuromodulatory effects on NMDA receptors that vary with subunit composition, membrane potential, and ligand concentration, which can drive varying combinations of potentiation of the receptor, blockade of the receptors ion channel, and reduced affinity for Glu (Figure 2

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Gopal S, Borovok I, Ofer A, Yanku M, Cohen G, Goebel W, Kreft J, Aharonowitz Y: A multidomain fusion protein in Listeria monocytogenes catalyzes the two primary activities for glutathione biosynthesis