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Oct-Dec 2004;25(5-6):455-73

10,12 Considering that AP2 is expressed in PGCs from E7.5 to E12.5, a period encompassing the entire germ cell migration period, our work supports the notion that AP2 is not only important for PGC specification but also critical for the maintenance of germ cell fate in migrating PGCs

The treatment increased the abundance of beneficial genera such as Lachnospiraceae , Ruminococcus , and Akkermansia

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Thiamine deficiency adversely affects the activity levels of these enzymes, with TK, through thiamine-dependent erythrocyte transketolase (ETK) activity, common biomarkers of thiamine status, since it is particularly sensitive to thiamine levels and AKD often exhibiting the earliest detectable changes (41)

Mechanistically, TRIM37 binds TRIM28 through its MATH domain and ubiquitinates TRIM28 via its RING domain, enhancing the TRIM37TRIM28 interaction and promoting the nuclear retention of TRIM37