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Regular exercise depletes muscle glycogen stores, lowers blood glucose, and improves glycemic control in T2DM over 8 weeks or more

In the second trial, SURPASS-2, tirzepatide administered at doses of 5 mg, 10 mg, or 15 mg showed superior efficacy compared to semaglutide (1 mg) in reducing body weight and HbA1c levels over 40 weeks in patients with T2DM inadequately controlled with metformin [66]

Gastrointestinal side effects may lead to treatment discontinuation in some patients, though severe cases remain rare and can be mitigated with appropriate monitoring (62)

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By maintaining open communication, asking the right questions, and being proactive about your health, you can manage any potential side effects and continue to benefit from your medication